Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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The Food and Drug Administration said its warning against the use of Viagra and other drugs containing sildenafil was based on several factors, including findings from a study in the Journal of the American Medical Association and found no serious adverse reactions were reported. In the case of the three drugs that have been found to cause allergic reactions, one was a blood thinner called rivastigmine and one was a blood thinner called tadalafil.
"The FDA has not found any serious adverse events associated with these drugs and the safety data was not collected in a timely manner," the agency said in a statement.
The study was funded by Pfizer, which makes Viagra, and Bayer, which makes Cialis. The FDA had not released the findings of the study on its website, but the agency has previously made similar findings in a review of other similar drugs.
It was the first time a drug was linked to a severe allergic reaction, and the FDA's warning was based on the findings from the study.
Viagra is the only drug that has been linked to a severe allergic reaction.
The FDA said in a statement: "These reports are consistent with the known safety profiles of the drugs and other similar drugs in the public database."
The warning comes on the heels of a study in the British Journal of Medicine which found the FDA had not reviewed the same drug to determine if it could cause a severe allergic reaction.
The FDA has not released the findings of the study on its website, but the agency has previously made similar findings in a review of other similar drugs.
Pfizer, which makes Viagra, has already announced to the British Medical Journal that it would review the drug data and make a "complete" list of all drugs it had found to cause severe allergic reactions.
In a statement the agency said: "We have not conducted any analysis that includes the results of these two studies."
The company said: "The FDA has not released any statements about the safety and efficacy of this drug or any other similar product. We do not have any statements that would suggest the use of these drugs would be associated with an increased risk of serious adverse reactions.
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Read:© 2012 The New York Times
This is an extended version of an interview with The Associated Press, and I am also credited with reporting.
Ranbir Bhutto, the US defence secretary, said: "This is an extended version of the interview with The Associated Press. I think the American public will pay for this drug."He said: "It's a huge pharmaceutical industry and a huge public trust. It is a major drug, it's a huge business, it's a big market and it's an enormous issue for a lot of people."
The drug industry has faced significant political pressure and is facing a number of drug recalls. The recall has caused some of the world's biggest pharma companies to recall products from a number of other countries.
In the US, a number of manufacturers are recalled.
Ranbir Bhutto, the US defence secretary, said: "It's a huge pharmaceutical industry and a huge public trust. It is a major drug, it's a big business, it's a big market and it's an enormous issue for a lot of people.
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